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Symbol
Name
ID

Vhl
von Hippel-Lindau tumor suppressor
MGI:103223

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes	Lymphadenopathy	Hepatosplenomegaly	Peritoneal abscess
Disease(s) Associated with VHL
pancreatic cancer

Mouse Phenotypes		decreased susceptibility to induced colitis	enlarged spleen	increased spleen weight	decreased lymphocyte cell number	increased leukocyte cell number	abnormal spleen morphology	increased spleen red pulp amount	decreased spleen white pulp amount	increased inflammatory response	kidney inflammation
Availability	Mouse Genotype	decreased susceptibility to induced colitis	enlarged spleen	increased spleen weight	decreased lymphocyte cell number	increased leukocyte cell number	abnormal spleen morphology	increased spleen red pulp amount	decreased spleen white pulp amount	increased inflammatory response	kidney inflammation
	Vhl^tm1Mcs/Vhl^tm1Mcs
	Hprt1^{tm1(Pck1-cre)Vhh}/Y Vhl^tm1Jae/Vhl^tm1Jae (conditional)
	Vhl^tm1Jae/Vhl^tm1Jae Lyz2^tm1(cre)Ifo/Lyz2⁺ (conditional)
	Tg(Fabp1-cre)1Jig/0 Vhl^tm1Jae/Vhl^tm1Jae (conditional)
	Vhl^tm1Jae/Vhl^tm1Jae Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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